Pyrimidine deoxyribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRSK1, DUT, and HDAC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleotide biosynthetic process activity versus BRSK1 in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRSK1 →	+0.977	+0.197	.004	<.001	3	6
OVARY	DUT →	+0.597	+0.776	<.001	.001	3	5
BLOOD_Leukemia	HDAC4 →	+1.383	+0.224	<.001	.002	3	5
SOFT_TISSUE	ZNF850 →	+0.936	+0.724	.003	.008	3	5
UPPER_AERODIGESTIVE_TRACT	PPM1D →	+0.808	+1.193	<.001	<.001	3	5
BLOOD_Leukemia	PKMYT1 →	+0.861	+0.267	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009221 vs BRSK1 — BLOOD_Leukemia

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