Pyrimidine ribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMNB2, MPRIP_S800, and RPL28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide biosynthetic process activity versus LMNB2 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LMNB2 →	-0.181	-0.037	.002	<.001	3	4
LSCC	MPRIP_S800 →	-0.447	-0.023	.002	.005	3	4
GBM	RPL28 →	-0.314	-0.033	.001	.001	3	4
PDAC	DHX57_S127 →	+0.478	+0.028	<.001	<.001	3	3
LUAD	MROH1 →	-0.282	-0.034	.004	.004	2	4
LUAD	NME7 →	+0.120	+0.038	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009220 vs LMNB2 — LSCC

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