Pyrimidine ribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1G2, C1QTNF3, and BOLA3P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide biosynthetic process activity versus ATP6V1G2 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP6V1G2 →	-0.653	-0.144	<.001	<.001	3	4
PDAC	C1QTNF3 →	-1.073	-0.129	.001	.003	3	4
HNSC	BOLA3P2 →	+0.310	+0.109	.009	.009	3	3
LSCC	C10orf99 →	-1.308	-0.132	.002	<.001	3	3
HNSC	CLN3 →	+0.303	+0.130	<.001	.001	3	3
HNSC	DNAJC19P6 →	+0.642	+0.135	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009220 vs ATP6V1G2 — GBM

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