Pyrimidine ribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, JUNB, and TUFT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide biosynthetic process activity versus TBC1D2 in LUNG_SCLC (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TBC1D2 →	-1.215	-0.357	.006	.002	3	5
BLOOD_Lymphoma	JUNB →	-2.580	-0.276	<.001	<.001	3	5
KIDNEY	TUFT1 →	-1.281	-0.203	.006	.001	3	5
BLOOD_Lymphoma	E2F2 →	+2.943	+0.273	<.001	<.001	3	4
BLOOD_Lymphoma	RAD54L →	+0.749	+0.227	.004	.005	3	4
BLOOD_Lymphoma	SDC4 →	-2.542	-0.252	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009220 vs TBC1D2 — LUNG_SCLC

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