Pyrimidine ribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAICS, CAD, and UBE2I, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide biosynthetic process activity versus PAICS in STOMACH (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PAICS →	+2.291	+1.621	<.001	.003	3	16
STOMACH	CAD →	+1.973	+1.288	<.001	.003	3	15
URINARY_TRACT	UBE2I →	+1.816	+1.602	.001	.003	3	15
STOMACH	PPP2R1A →	+1.235	+1.584	.003	.003	3	15
STOMACH	NME1 →	+2.872	+1.641	<.001	.002	3	15
STOMACH	NME2 →	+1.745	+1.662	.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009220 vs PAICS — STOMACH

Explore this scatter interactively →