Pyrimidine deoxyribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, TCEAL7, and E2F1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleotide metabolic process activity versus PIF1 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PIF1 →	+0.691	+0.165	.002	.003	3	5
UCEC	TCEAL7 →	-0.879	-0.154	<.001	.003	3	5
UCEC	E2F1 →	+0.736	+0.142	<.001	.001	3	5
UCEC	RAD54L →	+0.640	+0.205	.005	<.001	3	5
UCEC	ASF1B →	+0.731	+0.197	.006	<.001	3	4
GBM	PDE1A →	-0.553	-0.077	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009219 vs PIF1 — BRCA

Explore this scatter interactively →