Pyrimidine deoxyribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK25, RUBCN, and CNPPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleotide metabolic process activity versus STK25 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	STK25 →	+0.454	+1.334	<.001	.001	3	6
LIVER	RUBCN →	+0.638	+1.194	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CNPPD1 →	+0.578	+1.302	.003	<.001	2	6
LIVER	SLC38A4 →	-2.542	-1.397	.002	.007	3	4
OVARY	KCTD13 →	+1.143	+0.905	.001	.009	2	5
LUNG_NSCLC_LUSC	SMAD2 →	+1.782	+1.742	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009219 vs STK25 — LIVER

Explore this scatter interactively →