Pyrimidine ribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX50P1, SERBP1P1, and DHODH, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide metabolic process activity versus DDX50P1 in KIRC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	DDX50P1 →	+0.249	+0.029	<.001	<.001	3	24
LAML	SERBP1P1 →	+0.515	+0.036	<.001	<.001	3	24
UVM	DHODH →	+0.606	+0.023	.003	.001	2	24
ACC	HEATR1 →	+1.341	+0.037	<.001	<.001	3	23
KIRC	EIF4A1 →	+0.887	+0.033	<.001	<.001	3	23
ACC	FANCA →	+1.146	+0.031	<.001	.002	1	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009218 vs DDX50P1 — KIRC

Explore this scatter interactively →