Pyrimidine ribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD9_S566, ANLN_S485, and DNAJA4_S336, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide metabolic process activity versus BRD9_S566 in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BRD9_S566 →	-0.705	-0.026	<.001	.002	3	4
LUAD	ANLN_S485 →	+0.812	+0.036	.008	.005	3	4
PDAC	DNAJA4_S336 →	+0.563	+0.038	<.001	<.001	3	4
PDAC	KIFBP →	+0.149	+0.021	<.001	.001	3	4
GBM	WDR54 →	+0.296	+0.036	<.001	<.001	3	4
GBM	ZNF318_T161 →	-0.366	-0.046	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009218 vs BRD9_S566 — BRCA

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