Pyrimidine ribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBXA2R_S331, EPS8_S58, and CTU2_S508, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide metabolic process activity versus TBXA2R_S331 in BRCA (Pearson r = -0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBXA2R_S331 →	-1.087	-0.445	<.001	<.001	3	3
OV	EPS8_S58 →	-0.911	-0.412	<.001	<.001	3	3
OV	CTU2_S508 →	+1.199	+0.474	<.001	<.001	3	3
CCRCC	RAP1GAP2_S558 →	-1.925	-0.208	<.001	<.001	3	3
GBM	WDR77 →	+0.226	+0.169	<.001	<.001	3	3
LUAD	SRGAP1_S932 →	-0.666	-0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009218 vs TBXA2R_S331 — BRCA

Explore this scatter interactively →