Pyrimidine ribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, RAET1G, and CTSD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide metabolic process activity versus PNPT1 in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PNPT1 →	+1.332	+0.368	<.001	.005	3	5
BONE	RAET1G →	-1.275	-0.413	.002	.001	3	5
LUNG_NSCLC_LUAD	CTSD →	-1.268	-0.129	.001	.006	3	5
STOMACH	REXO1 →	+1.152	+0.289	<.001	<.001	3	5
LUNG_NSCLC_LUSC	TCF3 →	+1.525	+0.201	.006	.005	3	4
BLOOD_Leukemia	NAA15 →	+0.574	+0.206	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009218 vs PNPT1 — OVARY

Explore this scatter interactively →