Purine deoxyribonucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMHD1, LGALS9, and TRAJ24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleoside triphosphate metabolic process activity versus SAMHD1 in UCEC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMHD1 →	+0.991	+0.368	<.001	<.001	3	6
GBM	LGALS9 →	+0.839	+0.220	<.001	<.001	3	6
UCEC	TRAJ24 →	+1.461	+0.228	<.001	<.001	3	6
UCEC	TOMM20P2 →	+1.015	+0.226	.002	.002	3	6
HNSC	MCOLN2 →	+1.028	+0.206	<.001	<.001	3	6
HNSC	BTLA →	+0.832	+0.234	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009215 vs SAMHD1 — UCEC

Explore this scatter interactively →