Purine deoxyribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUK1, ARF1, and CXCR4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleoside triphosphate metabolic process activity versus GUK1 in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GUK1 →	+0.604	+1.501	.005	<.001	3	5
CNS	ARF1 →	+0.436	+1.070	<.001	.001	3	5
BLOOD_Leukemia	CXCR4 →	+4.211	+1.599	<.001	<.001	3	4
LUNG_SCLC	CCN1 →	-3.561	-1.065	.003	.007	3	4
LUNG_NSCLC_LUAD	SMOX →	-2.457	-1.216	.008	.008	3	3
URINARY_TRACT	ACTR3 →	+1.088	+1.753	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009215 vs GUK1 — SKIN

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