Cyclic nucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Cyclic nucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the THCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE7B, TEK, and PTPRB, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic nucleotide catabolic process activity versus PDE7B in THCA (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	PDE7B →	+1.532	+0.063	<.001	<.001	3	32
KICH	TEK →	+1.600	+0.058	<.001	<.001	3	30
KIRC	PTPRB →	+1.149	+0.044	<.001	<.001	3	30
TGCT	EMCN →	+1.247	+0.071	<.001	<.001	3	30
KIRC	PDE10A →	+1.500	+0.055	<.001	<.001	3	29
UCS	PDE4D →	+1.449	+0.072	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009214 vs PDE7B — THCA

Explore this scatter interactively →