Cyclic nucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Cyclic nucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, SUN2, and ERI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic nucleotide catabolic process activity versus ACTA2 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACTA2 →	+1.054	+0.536	<.001	.001	2	5
GBM	SUN2 →	+0.534	+0.828	<.001	<.001	3	3
GBM	ERI1 →	-0.396	-0.756	.004	.002	3	3
GBM	PLA2G4C →	+0.562	+0.614	<.001	<.001	3	3
GBM	SCN1B →	+0.536	+0.735	<.001	<.001	3	3
OV	CHCHD3 →	-0.366	-0.273	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009214 vs ACTA2 — CCRCC

Explore this scatter interactively →