Cyclic nucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Cyclic nucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP3, TFAP2A, and SRP54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP3 grouped by Cyclic nucleotide catabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LTBP3 →	-1.923	-1.745	.002	.002	3	4
URINARY_TRACT	TFAP2A →	-1.777	-1.450	.005	.008	3	4
OESOPHAGUS	SRP54 →	-1.211	-1.292	<.001	.001	3	3
OESOPHAGUS	SLC46A3 →	-1.181	-1.405	.006	<.001	3	3
OESOPHAGUS	RALGAPA1 →	-1.199	-1.351	.003	<.001	3	3
OESOPHAGUS	BEX5 →	-2.156	-1.415	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP3 by Cyclic nucleotide catabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →