Cyclic nucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Cyclic nucleotide catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPK1B, NPBWR1, and SRSF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPK1B grouped by Cyclic nucleotide catabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UPK1B →	-0.377	-0.142	.005	.002	3	5
SOFT_TISSUE	NPBWR1 →	-0.218	-0.143	.005	.002	3	5
LIVER	SRSF4 →	+0.160	+0.153	.003	.006	3	4
SOFT_TISSUE	CD46 →	+0.351	+0.154	.008	.008	3	4
BREAST	SEZ6L →	-0.196	-0.098	.003	<.001	3	3
BREAST	CCN4 →	+0.172	+0.079	.002	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPK1B by Cyclic nucleotide catabolic process activity — SOFT_TISSUE

Explore this box plot interactively →