Pyrimidine deoxyribonucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI44, USP18, and MX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside triphosphate metabolic process activity versus IFI44 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFI44 →	+1.110	+0.178	.005	<.001	3	5
HNSC	USP18 →	+1.087	+0.117	<.001	.001	3	5
BRCA	MX1 →	+1.165	+0.156	.001	<.001	3	5
UCEC	FANCB →	+0.660	+0.114	<.001	<.001	3	5
UCEC	E2F1 →	+0.858	+0.116	.001	<.001	3	4
UCEC	ASF1B →	+1.075	+0.147	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009211 vs IFI44 — HNSC

Explore this scatter interactively →