Pyrimidine deoxyribonucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDCA8_S219, EIF3H_S183, and TYMS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside triphosphate metabolic process activity versus CDCA8_S219 in UCEC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA8_S219 →	+0.742	+0.157	<.001	<.001	3	5
BRCA	EIF3H_S183 →	+0.562	+0.139	<.001	<.001	3	5
UCEC	TYMS →	+0.683	+0.143	<.001	<.001	3	4
LSCC	FEN1 →	+0.425	+0.145	<.001	<.001	3	4
BRCA	KIF2C →	+0.503	+0.142	.001	<.001	3	4
UCEC	LRWD1_S243 →	+1.044	+0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009211 vs CDCA8_S219 — UCEC

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