Pyrimidine deoxyribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NARS2, CREB3, and YES1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NARS2 grouped by Pyrimidine deoxyribonucleoside triphosphate metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NARS2 →	+0.579	+0.395	.006	.006	3	5
SOFT_TISSUE	CREB3 →	-0.725	-1.677	.004	<.001	3	4
CNS	YES1 →	-0.514	-1.108	.003	<.001	3	4
OESOPHAGUS	LEMD2 →	+0.710	+0.458	.002	<.001	3	3
OESOPHAGUS	CRIP1 →	+4.808	+0.430	.001	.005	3	3
LUNG_SCLC	RILPL2 →	-1.299	-0.225	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NARS2 by Pyrimidine deoxyribonucleoside triphosphate metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →