Pyrimidine deoxyribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP2, POLG2, and RPS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside triphosphate metabolic process activity versus LAMP2 in BLOOD_Lymphoma (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LAMP2 →	-1.111	-0.216	.003	.003	3	7
LARGE_INTESTINE	POLG2 →	+0.659	+0.308	.005	<.001	3	7
BREAST	RPS2 →	+0.650	+0.528	.001	.001	3	6
LUNG_SCLC	DUT →	+0.674	+0.241	.001	<.001	3	6
LIVER	SMARCC2 →	+1.040	+0.342	.004	.004	3	5
KIDNEY	MRPS5 →	+0.559	+0.273	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009211 vs LAMP2 — BLOOD_Lymphoma

Explore this scatter interactively →