Pyrimidine ribonucleoside triphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAD_S1859, RPGR_S518, and ZMYM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside triphosphate biosynthetic process activity versus CAD_S1859 in HNSC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CAD_S1859 →	+0.383	+0.061	<.001	.002	3	6
GBM	RPGR_S518 →	+0.405	+0.047	.001	<.001	3	5
LSCC	ZMYM4 →	+0.176	+0.031	<.001	<.001	3	5
HNSC	CCDC97_S264 →	+0.574	+0.055	.004	<.001	3	5
UCEC	NME7 →	+0.408	+0.090	<.001	<.001	3	5
BRCA	ZMYM4_S122 →	+0.284	+0.034	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009209 vs CAD_S1859 — HNSC

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