Pyrimidine ribonucleoside triphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEU1, TSPYL2, and P3H1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEU1 grouped by Pyrimidine ribonucleoside triphosphate biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEU1 →	-1.596	-1.785	<.001	<.001	3	4
OVARY	TSPYL2 →	+0.933	+0.649	.001	.004	3	3
CNS	P3H1 →	-1.328	-0.704	.001	.005	3	3
CNS	TMEM214 →	-0.668	-0.559	.008	.005	3	3
CNS	KDELR2 →	-0.918	-0.801	.001	<.001	3	3
CNS	ARHGAP24 →	-1.497	-0.752	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEU1 by Pyrimidine ribonucleoside triphosphate biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →