Pyrimidine ribonucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24D, CAD_S1859, and AGFG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside triphosphate metabolic process activity versus SEC24D in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEC24D →	+0.292	+0.029	.006	.001	3	5
LUAD	CAD_S1859 →	+0.476	+0.038	<.001	.002	3	5
LUAD	AGFG2 →	-0.291	-0.035	<.001	<.001	3	5
LUAD	GNG7 →	-0.291	-0.038	<.001	.003	3	5
UCEC	NME7 →	+0.220	+0.058	<.001	<.001	3	5
HNSC	PFN2 →	+0.627	+0.057	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009208 vs SEC24D — COAD

Explore this scatter interactively →