Pyrimidine ribonucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHCHD4, ANP32B, and DKC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside triphosphate metabolic process activity versus CHCHD4 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CHCHD4 →	+0.497	+0.322	.006	<.001	3	5
HNSC	ANP32B →	+0.535	+0.160	.004	.003	2	5
BRCA	DKC1 →	+0.469	+0.184	.001	<.001	3	3
OV	TBC1D8-AS1 →	-0.361	-0.190	.003	.003	3	3
PDAC	SEPTIN14P21 →	+0.031	+0.123	.002	<.001	3	3
PDAC	RNU6-85P →	+0.457	+0.137	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009208 vs CHCHD4 — OV

Explore this scatter interactively →