Pyrimidine ribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAM2, ARHGAP24, and KDELR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCAM2 grouped by Pyrimidine ribonucleoside triphosphate metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NCAM2 →	-1.276	-0.921	.001	.002	3	4
CNS	ARHGAP24 →	-1.474	-0.632	<.001	.007	3	4
SKIN	KDELR2 →	-0.896	-0.915	.008	.007	3	3
SKIN	UGGT1 →	-0.413	-0.658	.003	.002	3	3
SOFT_TISSUE	PHACTR2 →	-1.618	-0.283	.002	<.001	2	4
SOFT_TISSUE	NEU1 →	-1.304	-0.333	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCAM2 by Pyrimidine ribonucleoside triphosphate metabolic process activity — CNS

Explore this box plot interactively →