Pyrimidine ribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, SERINC3, and MTREX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside triphosphate metabolic process activity versus PNPT1 in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PNPT1 →	+0.869	+0.232	<.001	<.001	3	6
STOMACH	SERINC3 →	-1.394	-0.345	.002	.009	3	5
OVARY	MTREX →	+0.937	+0.259	.001	.008	1	7
STOMACH	CAD →	+1.060	+0.394	.005	.009	2	6
LUNG_NSCLC_LUSC	F3 →	-4.742	-0.330	<.001	.005	3	5
LUNG_NSCLC_LUSC	IMMT →	+0.842	+0.437	.007	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009208 vs PNPT1 — BLOOD_Leukemia

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