Deoxyribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM13B, FAM207A, and IQCH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM13B grouped by Deoxyribonucleoside triphosphate metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM13B →	+0.575	+1.094	.004	<.001	3	5
SKIN	FAM207A →	+0.407	+0.836	.005	.001	3	4
STOMACH	IQCH →	-1.151	-1.373	.006	<.001	2	5
OVARY	MRPL10 →	-0.747	-1.218	.002	.001	3	4
BLOOD_Myeloma	PSMD6 →	+0.598	+1.106	.008	.002	3	4
BLOOD_Myeloma	ATP2B1 →	+1.285	+1.497	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM13B by Deoxyribonucleoside triphosphate metabolic process activity — CNS

Explore this box plot interactively →