Deoxyribonucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSPN, HEG1, and IRS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside triphosphate metabolic process activity versus SSPN in LUNG_NSCLC_LUAD (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SSPN →	-1.404	-1.098	<.001	<.001	3	4
BONE	HEG1 →	-4.150	-1.691	.009	.001	3	4
BONE	IRS2 →	+3.562	+1.678	.005	<.001	3	4
OESOPHAGUS	RNF217 →	-1.976	-1.141	<.001	.002	3	4
SOFT_TISSUE	PDK1 →	+1.127	+1.606	<.001	<.001	3	4
OESOPHAGUS	TMCO6 →	-1.029	-1.457	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009200 vs SSPN — LUNG_NSCLC_LUAD

Explore this scatter interactively →