Pyrimidine ribonucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, ENTPD5, and DHX9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside diphosphate metabolic process activity versus SF3B3 in COAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SF3B3 →	+0.200	+0.035	<.001	<.001	3	6
PDAC	ENTPD5 →	+0.707	+0.054	<.001	<.001	3	6
COAD	DHX9 →	+0.188	+0.032	<.001	<.001	3	6
LUAD	CFDP1 →	+0.306	+0.043	<.001	<.001	3	6
PDAC	RPL29_S158 →	-0.533	-0.049	<.001	<.001	3	5
LUAD	CDH1 →	+0.388	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009193 vs SF3B3 — COAD

Explore this scatter interactively →