Pyrimidine ribonucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST1, SHMT1, and CD163, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside diphosphate metabolic process activity versus MAST1 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAST1 →	-0.784	-0.110	.001	<.001	3	3
LUAD	SHMT1 →	-0.407	-0.148	.005	<.001	3	3
UCEC	CD163 →	-0.897	-0.189	.008	.002	3	3
GBM	DRP2 →	-0.703	-0.095	<.001	<.001	3	3
GBM	TMOD2 →	-0.635	-0.118	<.001	<.001	3	3
GBM	TMCC2 →	-0.720	-0.104	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009193 vs MAST1 — GBM

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