Pyrimidine ribonucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTPD7, ENTPD5, and DHODH, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside diphosphate metabolic process activity versus ENTPD7 in STOMACH (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ENTPD7 →	+1.180	+0.084	<.001	.003	2	14
LIVER	ENTPD5 →	+1.684	+0.147	<.001	.001	3	12
PANCREAS	DHODH →	+0.853	+0.058	.001	.002	3	11
PANCREAS	NOLC1 →	+0.704	+0.039	.002	.003	3	11
SOFT_TISSUE	PDCD11 →	+0.984	+0.078	.002	.001	3	10
UPPER_AERODIGESTIVE_TRACT	IPO4 →	+1.262	+0.058	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009193 vs ENTPD7 — STOMACH

Explore this scatter interactively →