Pyrimidine ribonucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, PPM1G, and MYC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside diphosphate metabolic process activity versus ANKRD13B in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ANKRD13B →	+1.528	+0.267	.004	.004	3	7
SKIN	PPM1G →	+0.651	+0.755	<.001	.009	3	6
OVARY	MYC →	+1.662	+1.088	.001	.006	3	6
OVARY	MLX →	+0.557	+0.826	.001	.007	3	6
SKIN	RUVBL1 →	+0.803	+0.264	.003	.002	2	6
LUNG_NSCLC_LUAD	ANXA8 →	-2.076	-0.156	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009193 vs ANKRD13B — LIVER

Explore this scatter interactively →