Ribonucleoside diphosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside diphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC37L1, PRSS53, and MIOS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate catabolic process activity versus CDC37L1 in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDC37L1 →	+0.360	+0.183	.008	.008	2	5
UCEC	PRSS53 →	+0.333	+0.174	.001	.004	3	3
UCEC	MIOS →	+0.422	+0.169	.004	.007	3	3
UCEC	CPSF2 →	+0.290	+0.168	.004	<.001	3	3
GBM	RBM48 →	+0.244	+0.136	.001	.001	3	3
COAD	IGFALS →	-0.500	-0.155	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009191 vs CDC37L1 — BRCA

Explore this scatter interactively →