Ribonucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside diphosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH16, MYO1B, and SHISA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDH16 grouped by Ribonucleoside diphosphate catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CDH16 →	+0.233	+0.112	.009	.005	3	5
LUNG_NSCLC_LUSC	MYO1B →	-0.363	-0.067	.008	.005	3	4
SOFT_TISSUE	SHISA5 →	-0.216	-0.117	.007	.003	3	4
LUNG_NSCLC_LUAD	MYBL2 →	-0.431	-0.087	.002	.003	3	4
OESOPHAGUS	ZNF696 →	+0.224	+0.095	.002	<.001	3	4
PANCREAS	RGS3 →	+0.368	+0.103	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDH16 by Ribonucleoside diphosphate catabolic process activity — LIVER

Explore this box plot interactively →