Cyclic nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Cyclic nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXPH5, C15orf40, and CXCR4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXPH5 grouped by Cyclic nucleotide biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EXPH5 →	-0.558	-0.381	.008	.009	3	4
CNS	C15orf40 →	+0.516	+0.380	<.001	.009	3	4
SOFT_TISSUE	CXCR4 →	+3.302	+1.359	.002	.001	3	4
CNS	ITPKA →	+1.033	+0.617	.003	.002	3	3
URINARY_TRACT	PLXNB3 →	+2.477	+0.552	.004	.002	3	3
LARGE_INTESTINE	SECTM1 →	+1.881	+0.793	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXPH5 by Cyclic nucleotide biosynthetic process activity — CNS

Explore this box plot interactively →