Ribonucleoside diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside diphosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RUVBL1, DDX56, and AK4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate biosynthetic process activity versus RUVBL1 in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RUVBL1 →	+0.290	+0.053	.001	.001	3	9
LSCC	DDX56 →	+0.274	+0.053	<.001	.001	3	8
LSCC	AK4 →	+0.608	+0.068	<.001	<.001	3	8
HNSC	RUVBL2 →	+0.251	+0.070	<.001	.002	3	8
OV	PUF60 →	+0.774	+0.046	<.001	<.001	3	7
BRCA	SF3B3 →	+0.201	+0.041	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009188 vs RUVBL1 — PDAC

Explore this scatter interactively →