Ribonucleoside diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4, RPL37, and MED6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate biosynthetic process activity versus AK4 in LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AK4 →	+1.138	+0.156	<.001	.003	3	5
LUAD	RPL37 →	+0.479	+0.116	.005	.009	3	5
UCEC	MED6 →	-0.200	-0.096	.008	.004	3	4
CCRCC	GSDME →	+0.836	+0.171	<.001	.007	3	4
CCRCC	LRRN4 →	+0.790	+0.155	.004	.005	3	4
CCRCC	ITM2A →	-0.841	-0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009188 vs AK4 — LUAD

Explore this scatter interactively →