Ribonucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF441, VTA1, and TGFB1I1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF441 grouped by Ribonucleoside diphosphate biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF441 →	-0.527	-0.496	<.001	<.001	3	4
STOMACH	VTA1 →	+0.798	+0.301	.004	.004	3	4
LARGE_INTESTINE	TGFB1I1 →	-1.282	-0.243	.001	.001	3	4
OVARY	C9orf85 →	+0.579	+0.769	.004	.005	2	5
LUNG_NSCLC_LUAD	SLC35B1 →	-0.420	-0.294	<.001	.007	3	3
LUNG_NSCLC_LUAD	NAP1L2 →	-0.654	-0.297	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF441 by Ribonucleoside diphosphate biosynthetic process activity — LIVER

Explore this box plot interactively →