Ribonucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARF1, RRAGD, and RAB3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate biosynthetic process activity versus ARF1 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARF1 →	+0.721	+0.268	.002	.001	3	7
SKIN	RRAGD →	+2.356	+0.217	.001	.002	3	6
LARGE_INTESTINE	RAB3A →	+1.020	+0.225	.002	.004	3	6
PANCREAS	SCLY →	+1.022	+0.269	.003	.005	2	7
PANCREAS	PRPF38A →	+0.604	+0.354	.001	<.001	3	6
LIVER	CDK8 →	+0.685	+0.196	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009188 vs ARF1 — BLOOD_Lymphoma

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