Cyclic nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Cyclic nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRF5, LMOD1, and TAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic nucleotide metabolic process activity versus ADGRF5 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRF5 →	+0.811	+0.263	<.001	<.001	3	6
BRCA	LMOD1 →	+1.036	+0.637	<.001	<.001	3	6
GBM	TAL1 →	+0.803	+0.963	<.001	<.001	3	5
UCEC	TSPAN7 →	+1.071	+0.332	<.001	.001	3	5
GBM	SCN2B →	+0.965	+0.642	<.001	<.001	3	5
BRCA	ATP1A2 →	+0.514	+0.479	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009187 vs ADGRF5 — LSCC

Explore this scatter interactively →