Cyclic nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Cyclic nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABARAPL1, CORO2B, and ANKRD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic nucleotide metabolic process activity versus GABARAPL1 in LIVER (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GABARAPL1 →	-1.822	-0.321	.006	.001	3	4
BONE	CORO2B →	+2.865	+0.508	.009	.003	3	4
URINARY_TRACT	ANKRD7 →	+1.430	+0.377	<.001	<.001	3	4
URINARY_TRACT	ZNF775 →	+1.087	+0.290	<.001	.007	3	4
URINARY_TRACT	C8orf88 →	+2.708	+0.427	.001	<.001	3	4
BREAST	PGAP3 →	-1.653	-0.402	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009187 vs GABARAPL1 — LIVER

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