Deoxyribonucleoside diphosphate metabolic process

pathway activity — cross-omics
GO:0009186Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISG15, NUDT18, and ETV7, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
MESOISG15 →+2.131+0.082<.001<.001327
DLBCNUDT18 →+1.105+0.109<.001<.001327
THYMETV7 →+1.575+0.079<.001<.001326
BLCAHLA-F →+1.251+0.058<.001<.001326
BLCAPSMB9 →+1.458+0.056<.001<.001326
BLCAIFI35 →+1.123+0.074<.001<.001326
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration