Ribonucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNG7, CHRDL1, and TARS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate metabolic process activity versus GNG7 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GNG7 →	-0.427	-0.097	<.001	<.001	3	5
LSCC	CHRDL1 →	-1.005	-0.104	.001	.002	3	4
OV	TARS1 →	+0.449	+0.139	.001	.003	3	4
PDAC	SELENOI →	+0.214	+0.085	.003	.004	3	4
PDAC	ADAMTS10 →	-0.408	-0.113	.002	.004	2	5
PDAC	CDC25A →	+0.398	+0.115	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009185 vs GNG7 — LSCC

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