Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, SPI1, and FCGR2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside monophosphate metabolic process activity versus IL21R in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL21R →	+0.755	+0.172	.003	.001	3	8
OV	SPI1 →	+0.935	+0.119	.005	.009	3	7
OV	FCGR2B →	+1.095	+0.215	<.001	<.001	3	7
LSCC	BTK →	+0.593	+0.118	.004	.002	3	7
LUAD	LINC02611 →	+0.219	+0.092	.004	<.001	3	7
OV	SH2B3 →	+0.702	+0.133	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009176 vs IL21R — OV

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