Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXLNA, MAP3K3, and RPGRIP1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXLNA grouped by Pyrimidine deoxyribonucleoside monophosphate metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TXLNA →	-0.879	-0.303	<.001	<.001	3	5
BONE	MAP3K3 →	-1.919	-0.427	.001	.001	3	5
LUNG_SCLC	RPGRIP1L →	-0.952	-0.242	.003	<.001	3	4
PANCREAS	RIPK3 →	+2.313	+0.391	<.001	.001	3	4
PANCREAS	ADCY3 →	-0.780	-0.331	.001	.005	3	4
PANCREAS	ARL3 →	-1.113	-0.366	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXLNA by Pyrimidine deoxyribonucleoside monophosphate metabolic process activity — PANCREAS

Explore this box plot interactively →