Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR37, ATXN7L3B, and FUCA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside monophosphate metabolic process activity versus WDR37 in KIDNEY (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	WDR37 →	+1.097	+1.683	<.001	.009	3	5
BLOOD_Leukemia	ATXN7L3B →	+0.970	+0.365	<.001	.001	3	5
BLOOD_Leukemia	FUCA2 →	-3.670	-0.252	<.001	<.001	3	5
BLOOD_Leukemia	FOXK2 →	+0.581	+0.336	<.001	.005	3	5
PANCREAS	CLDN11 →	-4.031	-0.948	<.001	.007	3	4
BLOOD_Leukemia	ZNF280C →	+0.515	+0.231	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009176 vs WDR37 — KIDNEY

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