Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, RRM1, and MCM5, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside monophosphate metabolic process activity versus RRM2 in PANCREAS (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RRM2 →	+3.511	+1.015	<.001	.008	3	11
BLOOD_Lymphoma	RRM1 →	+0.894	+0.244	<.001	.004	3	10
UPPER_AERODIGESTIVE_TRACT	MCM5 →	+1.244	+0.968	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	DUT →	+1.070	+0.919	.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	MCM2 →	+1.470	+0.997	<.001	<.001	3	8
CNS	MCMBP →	+1.079	+0.898	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009176 vs RRM2 — PANCREAS

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