Pyrimidine ribonucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSTR4, RPE, and USP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSTR4 grouped by Pyrimidine ribonucleoside monophosphate biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SSTR4 →	+0.121	+0.068	.001	<.001	3	4
PANCREAS	RPE →	-0.112	-0.074	.005	.001	3	4
LUNG_SCLC	USP5 →	-0.302	-0.090	.005	<.001	3	4
STOMACH	PFKP →	+0.121	+0.090	.002	.001	3	4
CNS	HYAL2 →	+0.210	+0.078	<.001	<.001	3	4
STOMACH	CIRBP →	-0.195	-0.105	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSTR4 by Pyrimidine ribonucleoside monophosphate biosynthetic process activity — BREAST

Explore this box plot interactively →