Pyrimidine ribonucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, ATAD3A, and SERINC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate biosynthetic process activity versus TBC1D2 in BLOOD_Lymphoma (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TBC1D2 →	-1.072	-0.252	<.001	<.001	3	7
LUNG_NSCLC_LUAD	ATAD3A →	+0.864	+0.785	<.001	.001	3	5
LARGE_INTESTINE	SERINC3 →	-0.596	-0.844	.009	.008	3	5
URINARY_TRACT	FAM162A →	+1.512	+1.345	<.001	.005	3	4
LIVER	PCBP1 →	+0.639	+1.235	.001	.002	3	4
LUNG_SCLC	GADD45B →	-1.733	-0.281	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009174 vs TBC1D2 — BLOOD_Lymphoma

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